Manfred Kansy : rechercher sur Z-Library

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1

Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Kansy, Manfred, Senner, Frank, Gubernator, Klaus

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 132 KB

english, 1998

2

Fluorine in Medicinal Chemistry

Hans-Joachim Böhm, David Banner, Stefanie Bendels, Manfred Kansy, Bernd Kuhn, Klaus Müller, Ulrike Obst-Sander, Martin Stahl

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 218 KB

english, 2004

3

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

Stefanie Bendels, Manfred Kansy, Björn Wagner, Jörg Huwyler

Journal:

European Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 541 KB

english, 2008

4

Extending pKa prediction accuracy: High-throughput pKa measurements to understand pKa modulation of new chemical series

Francesca Milletti, Loriano Storchi, Laura Goracci, Stefanie Bendels, Bjoern Wagner, Manfred Kansy, Gabriele Cruciani

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 383 KB

english, 2010

5

Coexistence of passive and carrier-mediated processes in drug transport

Sugano, Kiyohiko, Kansy, Manfred, Artursson, Per, Avdeef, Alex, Bendels, Stefanie, Di, Li, Ecker, Gerhard F., Faller, Bernard, Fischer, Holger, Gerebtzoff, Grégori

Journal:

Nature Reviews Drug Discovery

Année:

2010

Langue:

english

Fichier:

PDF, 599 KB

english, 2010

6

High throughput solubility measurement in drug discovery and development

Jochem Alsenz, Manfred Kansy

Journal:

Advanced Drug Delivery Reviews

Année:

2007

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2007

7

On the polarity of partially fluorinated methyl groups

Huchet, Quentin A., Kuhn, Bernd, Wagner, Björn, Fischer, Holger, Kansy, Manfred, Zimmerli, Daniel, Carreira, Erick M., Müller, Klaus

Journal:

Journal of Fluorine Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2013

8

Safety screening in early drug discovery: An optimized assay panel

Bendels, Stefanie, Bissantz, Caterina, Fasching, Bernhard, Gerebtzoff, Grégori, Guba, Wolfgang, Kansy, Manfred, Migeon, Jacques, Mohr, Susanne, Peters, Jens-Uwe, Tillier, Fabien, Wyler, René, Lerner,

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2019

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2019

9

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

Année:

2020

Fichier:

PDF, 1.27 MB

2020

10

Hochaffine Inhibitoren der tRNA-Guanin-Transglycosylase, eines Schlüsselenzyms in der Pathogenese der Shigellen-Ruhr: ladungsverstärkte Wasserstoffbrücken

Simone R. Hörtner, Tina Ritschel, Bernhard Stengl, Christian Kramer, W. Bernd Schweizer, Björn Wagner, Manfred Kansy, Gerhard Klebe, François Diederich

Journal:

Angewandte Chemie

Année:

2007

Langue:

german

Fichier:

PDF, 446 KB

german, 2007

11

Potent Inhibitors of tRNA-Guanine Transglycosylase, an Enzyme Linked to the Pathogenicity of the Shigella Bacterium: Charge-Assisted Hydrogen Bonding

Simone R. Hörtner, Tina Ritschel, Bernhard Stengl, Christian Kramer, W. Bernd Schweizer, Björn Wagner, Manfred Kansy, Gerhard Klebe, François Diederich

Journal:

Angewandte Chemie International Edition

Année:

2007

Langue:

english

Fichier:

PDF, 462 KB

english, 2007

12

Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles

Jacob A. Olsen, David W. Banner, Paul Seiler, Björn Wagner, Thomas Tschopp, Ulrike Obst-Sander, Manfred Kansy, Klaus Müller, François Diederich

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 364 KB

english, 2004

13

A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values

Eliane Schweizer, Anja Hoffmann-Röder, Kaspar Schärer, Jacob A. Olsen, Christoph Fäh, Paul Seiler, Ulrike Obst-Sander, Björn Wagner, Manfred Kansy, François Diederich

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 392 KB

english, 2006

14

Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket

Anja Hoffmann-Röder, Eliane Schweizer, Jonas Egger, Paul Seiler, Ulrike Obst-Sander, Björn Wagner, Manfred Kansy, David W. Banner, François Diederich

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 493 KB

english, 2006

15

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

Jens-Uwe Peters, Patrick Schnider, Patrizio Mattei, Manfred Kansy

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 586 KB

english, 2009

16

PAMPA—critical factors for better predictions of absorption

Alex Avdeef, Stefanie Bendels, Li Di, Bernard Faller, Manfred Kansy, Kiyohiko Sugano, Yukinori Yamauchi

Journal:

Journal of Pharmaceutical Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2007

17

Polymere Protonenschwämme, 1. Synthese von Monomeren auf der Basis von Naphthalin und Fluoren

Manfred L. Hallensleben, Hartmut Kansy

Journal:

Macromolecular Chemistry and Physics

Année:

1989

Langue:

german

Fichier:

PDF, 407 KB

german, 1989

18

A potentiometric titration method for the crystallization of drug-like organic molecules

Lei Du-Cuny, Jörg Huwyler, Holger Fischer, Manfred Kansy

Journal:

International Journal of Pharmaceutics

Année:

2007

Langue:

english

Fichier:

PDF, 696 KB

english, 2007

19

Computational aqueous solubility prediction for drug-like compounds in congeneric series

Lei Du-Cuny, Jörg Huwyler, Michael Wiese, Manfred Kansy

Journal:

European Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 893 KB

english, 2008

20

Piperidine-renin inhibitors compounds with improved physicochemical properties

Rolf Güller, Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Georges Hirth, Christian Jenny, Manfred Kansy, François Montavon, Marcel Müller, Christian Oefner, Heinz Stadler, Eric Vieira, Ma

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 346 KB

english, 1999

21

Pyrimethamin-resistantPlasmodium falciparumlack cross-resistance to methotrexate and 2,4-diamino-5-(substituted benzyl) pyrimidines

Rolf D. Walter, Bärbel Bergmann, Manfred Kansy, Michael Wiese, Joachim K. Seydel

Journal:

Parasitology Research

Année:

1991

Langue:

english

Fichier:

PDF, 591 KB

english, 1991

22

PAMPA–Excipient Classification Gradient Map

Stefanie Bendels, Oksana Tsinman, Björn Wagner, Dana Lipp, Isabelle Parrilla, Manfred Kansy, Alex Avdeef

Journal:

Pharmaceutical Research

Année:

2006

Langue:

english

Fichier:

PDF, 699 KB

english, 2006

23

Solubility-Excipient Classification Gradient Maps

Alex Avdeef, Stefanie Bendels, Oksana Tsinman, Konstantin Tsinman, Manfred Kansy

Journal:

Pharmaceutical Research

Année:

2007

Langue:

english

Fichier:

PDF, 887 KB

english, 2007

24

An aminomethylpyrimidine DPP-IV inhibitor with improved properties

Jens-Uwe Peters, Daniel Hunziker, Holger Fischer, Manfred Kansy, Silja Weber, Stéphane Kritter, Aranka Müller, Angelina Wallier, Fabienne Ricklin, Markus Boehringer, Sonia Maria Poli, Miklos Csato, Be

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 262 KB

english, 2004

25

A fluorine scan of non-peptidic inhibitors of neprilysin: Fluorophobic and fluorophilic regions in an enzyme active site

Martin Morgenthaler, Johannes D. Aebi, Fiona Grüninger, Daniel Mona, Björn Wagner, Manfred Kansy, François Diederich

Journal:

Journal of Fluorine Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2008

26

Haem polymerization in malaria

Ridley, Robert G., Dorn, Arnulf, Matile, Hugues, Kansy, Manfred

Journal:

Année:

1995

Fichier:

PDF, 655 KB

1995

27

From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA–Guanine Transglycosylase: Replacement of Protein–Ligand Hydrogen Bonding by Importing Water Clusters

Luzi Jakob Barandun, Florian Immekus, Dr. Philipp C. Kohler, Sandro Tonazzi, Björn Wagner, Severin Wendelspiess, Dr. Tina Ritschel, Dr. Andreas Heine, Dr. Manfred Kansy, Prof. Dr. Gerhard Klebe, Prof.

Journal:

Chemistry - A European Journal

Année:

2012

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2012

28

Design of a New Substituted 2,4-Diamino-5-benzylpyrimidine as Inhibitor of Bacterial Dihydrofolate Reductase Assisted by Molecular Graphics

Karl-H. Czaplinsky, Manfred Kansy, Joachim K. Seydel, Rolf Haller

Journal:

Molecular Informatics

Année:

1987

Langue:

english

Fichier:

PDF, 275 KB

english, 1987

29

Integrating molecular design resources within modern drug discovery research: the Roche experience

Martin Stahl, Wolfgang Guba, Manfred Kansy

Journal:

Drug Discovery Today

Année:

2006

Langue:

english

Fichier:

PDF, 456 KB

english, 2006

30

Can we discover pharmacological promiscuity early in the drug discovery process?

Jens-Uwe Peters, Jérôme Hert, Caterina Bissantz, Alexander Hillebrecht, Grégori Gerebtzoff, Stefanie Bendels, Fabien Tillier, Jacques Migeon, Holger Fischer, Wolfgang Guba, Manfred Kansy

Journal:

Drug Discovery Today

Année:

2012

Langue:

english

Fichier:

PDF, 633 KB

english, 2012

31

Permeation of permanently positive charged molecules through artificial membranes—Influence of physico-chemical properties

Holger Fischer, Manfred Kansy, Alex Avdeef, Frank Senner

Journal:

European Journal of Pharmaceutical Sciences

Année:

2007

Langue:

english

Fichier:

PDF, 473 KB

english, 2007

32

Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

Alex Avdeef, Manfred Kansy, Stefanie Bendels, Konstantin Tsinman

Journal:

European Journal of Pharmaceutical Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2008

33

Predicting plasma protein binding of drugs: a new approach

Nicole A Kratochwil, Walter Huber, Francis Müller, Manfred Kansy, Paul R Gerber

Journal:

Biochemical Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 426 KB

english, 2002

34

Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors

Schweizer, Eliane, Hoffmann-R?der, Anja, Olsen, Jacob A., Seiler, Paul, Obst-Sander, Ulrike, Wagner, Bj?rn, Kansy, Manfred, Banner, David W., Diederich, Fran?ois

Journal:

Organic & Biomolecular Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 501 KB

english, 2006

35

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Li Di, Per Artursson, Alex Avdeef, Gerhard F. Ecker, Bernard Faller, Holger Fischer, J. Brian Houston, Manfred Kansy, Edward H. Kerns, Stefanie D. Krämer, Hans Lennernäs, Kiyohiko Sugano

Journal:

Drug Discovery Today

Année:

2012

Langue:

english

Fichier:

PDF, 518 KB

english, 2012

36

Model-based relationship between the microbial transformation rate of organic chemicals and their physicochemical properties

Štefan Baláž, Michael Wiese, Manfred Kansy, Han-lin Chi, Joachim K. Seydel

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 903 KB

english, 1989

37

Advances in screening for membrane permeability: high-resolution PAMPA for medicinal chemists

Manfred Kansy, Alex Avdeef, Holger Fischer

Journal:

Drug Discovery Today: Technologies

Année:

2004

Langue:

english

Fichier:

PDF, 211 KB

english, 2004

38

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C?F?CN interactions

Olsen, Jacob, Seiler, Paul, Wagner, Bj�rn, Fischer, Holger, Tschopp, Thomas, Obst-Sander, Ulrike, Banner, David W., Kansy, Manfred, M�ller, Klaus, Diederich, Fran�ois

Journal:

Organic & Biomolecular Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 572 KB

english, 2004

39

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Roche, Olivier, Schneider, Petra, Zuegge, Jochen, Guba, Wolfgang, Kansy, Manfred, Alanine, Alexander, Bleicher, Konrad, Danel, Franck, Gutknecht, Eva-Maria, Rogers-Evans, Mark, Neidhart, Werner, Stald

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 134 KB

english, 2002

40

Physicochemical characterization and in vitro permeation of an indirubin derivative

Heshmati, Nasim, Wagner, Bjoern, Cheng, Xinlai, Scholz, Therese, Kansy, Manfred, Eisenbrand, Gerhard, Fricker, Gert

Journal:

European Journal of Pharmaceutical Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 931 KB

english, 2013

41

Comparative Evaluation of in Silico Systems for Ames Test Mutagenicity Prediction: Scope and Limitations

Hillebrecht, Alexander, Muster, Wolfgang, Brigo, Alessandro, Kansy, Manfred, Weiser, Thomas, Singer, Thomas

Journal:

Chemical Research in Toxicology

Année:

2011

Langue:

english

Fichier:

PDF, 1.93 MB

english, 2011

42

pKa determination by 1H NMR spectroscopy – An old methodology revisited

Bezençon, Jacqueline, Wittwer, Matthias B., Cutting, Brian, Smieško, Martin, Wagner, Bjoern, Kansy, Manfred, Ernst, Beat

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2014

Langue:

english

Fichier:

PDF, 4.35 MB

english, 2014

43

Fail early and learn fast – how early safety testing impacts drug attrition

Mohr, Susanne, Kansy, Manfred, Lühe, Anke, Singer, Thomas, Weiser, Thomas

Journal:

Toxicology Letters

Année:

2013

Langue:

english

Fichier:

PDF, 57 KB

english, 2013

44

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Smith, Dennis, Artursson, Per, Avdeef, Alex, Di, Li, Ecker, Gerhard F., Faller, Bernard, Houston, J. Brian, Kansy, Manfred, Kerns, Edward H., Krämer, Stefanie D., Lennernäs, Hans, van de Waterbeemd, H

Journal:

Molecular Pharmaceutics

Année:

2014

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2014

45

Self-assembly, DNA Complexation, and pH Response of Amphiphilic Dendrimers for Gene Transfection

Guillot-Nieckowski, Marine, Joester, Derk, Stöhr, Meike, Losson, Myriam, Adrian, Marc, Wagner, Bjoern, Kansy, Manfred, Heinzelmann, Harry, Pugin, Raphaël, Diederich, François, Gallani, Jean-Louis

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 801 KB

english, 2007

46

Carrier Mediated Distribution System (CAMDIS): A new approach for the measurement of octanol/water distribution coefficients

Wagner, Bjoern, Fischer, Holger, Kansy, Manfred, Seelig, Anna, Assmus, Frauke

Journal:

European Journal of Pharmaceutical Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 960 KB

english, 2015

47

Quantifying the impact of transporters on cellular drug permeability

Matsson, Pär, Fenu, Luca A., Lundquist, Patrik, Wiśniewski, Jacek R., Kansy, Manfred, Artursson, Per

Journal:

Trends in Pharmacological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 819 KB

english, 2015

48

Addendum to ‘Quantifying the impact of transporters on cellular drug permeability’

Matsson, Pär, Fenu, Luca A., Lundquist, Patrik, Wiśniewski, Jacek R., Kansy, Manfred, Artursson, Per

Journal:

Trends in Pharmacological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 106 KB

english, 2015

49

Fluorination Patterning: A Study of Structural Motifs that Impact Physicochemical Properties of Relevance to Drug Discovery

Huchet, Quentin A., Kuhn, Bernd, Wagner, Björn, Kratochwil, Nicole A., Fischer, Holger, Kansy, Manfred, Zimmerli, Daniel, Carreira, Erick M, Müller, Klaus

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 3.01 MB

english, 2015

50

Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

Dehmlow, Henrietta, Ackermann, Jean, Aebi, Johannes, Blum-Kaelin, Denise, Chucholowski, Alexander, Coassolo, Philippe, Hartman, Peter, Kansy, Manfred, Märki, Hans Peter, Morand, Olivier, Von Der Mark,

Journal:

CHIMIA International Journal for Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 645 KB

english, 2005